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(OI; Brittle Bone Disease)
|The Bones of the Body|
|Copyright © Nucleus Medical Media, Inc.|
The gene that controls the making of collagen—an important element in bones and connective tissues
- Most common cause of OI.
- Most often caused by a random change in the gene. Not often associated with a family history.
Gene that controls proteins in cartilage
- Less common cause of OI.
- An inherited genetic change from parents. There is often a family history.
- Bone pain
- Hearing loss
- Whites of the eyes may have a blue, purple, or gray tint
- Bone deformity
- Short height
- Loose joints and muscle weakness
- Triangular face
- Brittle teeth
- Breathing problems
- Bruising easily
- Preventing health problems
- Improving independence and mobility
- Developing bone and muscle strength
- Medication called bisphosphonates—to increase bone mineral density
- Physical therapy—for range of motion and muscular strength exercises
- Surgical implant of rods into long bones—to provide strength and prevent or correct deformities
- Monitoring for fractures or scoliosis
- Assistive devices like braces, canes, or wheelchairs—may be needed with certain types of OI
- Dental procedures
- Exercise—swimming is often an ideal and safe activity
- Good nutrition
- Not smoking
- Avoiding excessive amounts of alcohol
National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.niams.nih.gov
Osteogenesis Imperfecta Foundation http://www.oif.org
Canadian Orthopaedic Foundation http://www.canorth.org
The Hospital for Sick Children http://www.sickkids.ca
Osteogenesis imperfecta. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us. Updated May 10, 2013. Accessed August 6, 2013.
Chevrel G, Meunier PJ. Osteogenesis imperfecta: lifelong management is imperative and feasible. Joint Bone Spine. 2001;68:125-129.
Types of OI. Osteogenesis Imperfecta Foundation website. Available at: http://www.oif.org/site/PageServer?pagename=AOI%5FTypes. Accessed August 6, 2013.
- Reviewer: Michael Woods, MD
- Review Date: 08/2013
- Update Date: 05/11/2013