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- The type of cell that is involved
- The patterns of growth
- Slow growing lymphomas
- Aggressive lymphomas
|The Lymphatic System|
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- History of chemotherapy and radiation therapy
- Infections involving the immune system (eg, HIV/AIDS , Epstein-Barr virus)
- Chronic hepatitis C infection
- Genetic conditions (eg, ataxia telangiectasia, X-linked lymphoproliferative disease, Wiskott-Aldrich syndrome)
- A parent had non-Hodgkin lymphoma, especially if they had it at an early age
- Painless swelling of the neck, underarm, groin, or any other lymph node area
- Unexplained fever
- Sore throat
- Constant fatigue
- Unexplained weight loss
- Itchy skin, especially on the legs and feet
- Bone and joint pain
- Chest pain or shortness of breath
- Blood and urine tests
- Chest x-ray —takes a picture of structures inside the chest to look for enlarged lymph nodes
- CT scan —makes pictures of structures inside the body to look for lymphomas in the abdomen, head, pelvis, chest, and neck
- Lymph node biopsy —to look for cancer
- Bone marrow aspiration and biopsy —a small amount of bone marrow (aspiration) and bone are removed to determine the extent of lymphoma
- Spinal tap —a small amount of cerebrospinal fluid is removed and examined to determine the extent of lymphoma
- PET scan —radioactive solution is injected into a vein so that a special camera can look for lymphoma throughout the body
Chemotherapy and Radiation Therapy
- Bone marrow transplantation —Bone marrow is removed, treated, and frozen. Large doses of chemotherapy and/or radiation therapy are applied to kill the cancer cells. After treatment, the bone marrow is replaced via a vein. Marrow may also be donated from a healthy donor.
- Peripheral stem cell transplant—Stem cells are very immature cells that produce blood cells. They are removed from circulating blood before chemotherapy or radiation treatment. The cells are replaced after treatment. These cells can develop new healthy cells.
American Cancer Society http://www.cancer.org/
Leukemia and Lymphoma Society http://www.leukemia-lymphoma.org/
Canadian Cancer Society http://www.cancer.ca/
Lymphoma Foundation Canada http://www.lymphoma.ca/
American Cancer Society. Non-Hodgkin’s lymphoma in children. American Cancer Society website. Available at: http://www.cancer.org/Cancer/Non-HodgkinLymphomainChildren/DetailedGuide/non-hodgkin-lymphoma-in-children-non-hodgkin-lymphomain-children . Updated July 8, 2009. Accessed July 7, 2010.
Children’s Hospital of Wisconsin. Non-Hodgkin’s lymphoma. Children’s Hospital of Wisconsin website. Available at: http://www.chw.org/display/PPF/DocID/21526/router.asp . Accessed July 7, 2010.
DynaMed Editorial Team. Non-Hodgkin’s lymphoma. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated May 25, 2010. Accessed July 7, 2010.
McCoy K. Adult non-Hodgkin’s lymphoma. EBSCO Health Library website. Available at: http://www.ebscohost.com/healthLibrary/ . Updated October 2009. Accessed July 7, 2010.
2/5/2013 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Kharazmi E, Fallah M, Sundquist K, et al. Familial risk of early and late onset cancer: nationwide prospective cohort study. BMJ . 2012;345:e8076.
- Reviewer: Michael Woods, MD
- Review Date: 03/2013
- Update Date: 03/01/2013