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|Normal Open Sutures in Infant Skull (Pink)|
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- Parents with the disorder
- Parents who do not have the disorder, but who carry the gene that causes the disorder.
- Fathers at an older age at the time of conception
- Flattened top and back of head
- Flattened forehead and temples
- Mid-face that is small and located further back in the face than normal
- Beak-like nose
- Compression of nasal passages, often causing reduced airflow through the nose
- Large, protruding lower jaw
- Misalignment of teeth
- High-arched, narrow palate, or cleft palate
- Problems with development of the inner ear and hearing loss
- Meniere’s disease—lightheadedness, vertigo, or ringing in the ears
- Problems with the eyes, including vision problems, crossed eyes, or involuntary eye movement
- Curvature of the spine
- Acanthosis nigricans—small, dark, velvety patches of skin
- Hydrocephalus—build up of fluid in the skull
- Craniectomy—removal and replacement of portions of the skull. Done as early as possible after birth to prevent damage to the brain. It will also help to maintain a skull shape that is as normal as possible.
- Surgery to treat protrusion of one or both eyeballs—adjustments are made to the bones surrounding the eye sockets
- Surgery to treat protruding lower jaw—to normalize the appearance of the jaw
- Surgery to repair a cleft palate
Eye and Ear Treatment
Cleft Palate Foundation http://www.cleftline.org
Office of Rare Diseases Research—National Institutes of Health http://rarediseases.info.nih.gov
Health Canada http://www.hc-sc.gc.ca
Sick Kids—The Hospital for Sick Children http://www.sickkids.ca
Abnormal timing in the prenatal ossification of vertebral column and hand in Crouzon syndrome. Am J Med Genet. 2000 Feb 28.
Craniosynostosis. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated November 28, 2011. Accessed June 3, 2014.
Crouzon Syndrome. NIH Office of Rare Disease website. Available at: http://rarediseases.info.nih.gov/GARD/QnASelected.aspx?diseaseID=6206. Updated March 24, 2011. Accessed June 3, 2014.
Dalben Gda S, Costa B, et al. Oral health status of children with syndromic craniosynostosis. Oral Health Prev Dent. 2006;4(3):173-179.
Perlyn CA, Morriss-Kay G, et al. A model for the pharmacological treatment of crouzon syndrome. Neurosurgery. 2006 Jul;59(1):210-215.
- Reviewer: Kari Kassir, MD
- Review Date: 06/2014
- Update Date: 06/03/2014