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Depression (Mild to Moderate)
Principal Proposed Natural Treatments
Other Proposed Natural Treatments
- 5-Hydroxytryptophan (5-HTP)
- Dehydroepiandrosterone (DHEA)
- Fish Oil
- Hatha Yoga
- Music Therapy
- Rhodiola Rosea
- S-Adenosylmethionine (SAMe)
- Saffron ( Crocus sativus )
- Traditional Chinese Herbal Medicine
- Vitamin B 6
- Vitamin B 12
Principal Proposed Natural Treatments
What Is the Scientific Evidence for St. John's Wort?
Other Proposed Natural Treatments
Repetitive Transcranial Magnetic Stimulation
Other Herbs and Supplements
Herbs and Supplements to Use Only With Caution
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15 Laakmann G, Schule C, Baghai T, et al. St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry. 1998;31(suppl):54-59.
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76 Bell KM, Potkin SG, Carreon D, et al. S-adenosylmethionine blood levels in major depression: changes with drug treatment. Acta Neurol Scand Suppl. 1994;154:15-18.
77 Echols JC, Naidoo U, Salzman C. SAMe (S-adenosylmethionine). Harv Rev Psychiatry. 2000;8:84-90.
78 Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.
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98 Coppen A, Bailey J. Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial. J Affect Disord. 2000;60:121-130.
99 Meyer T, Broocks A. Therapeutic impact of exercise on psychiatric diseases: guidelines for exercise testing and prescription. Sports Med. 2000;30:269-279.
100 Eich H, Agelink MW, Lehmann E, et al. Acupuncture in patients with minor depressive episodes and generalized anxiety. Results of an experimental study [in German; English abstract]. Fortschr Neurol Psychiatr. 2000;68:137-144.
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105 Padberg F, Zwanzger P, Thoma H, et al. Repetitive transcranial magnetic stimulation (rTMS) in pharmacotherapy-refractory major depression: comparative study of fast, slow and sham rTMS. Psychiatry Res. 1999;88:163-171.
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109 Garzya G, Corallo D, Fiore A, et al. Evaluation of the effects of L-acetylcarnitine on senile patients suffering from depression. Drugs Exp Clin Res. 1990;16:101-106.
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113 Wolkowitz OM, Reus VI, Keebler A, et al. Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psychiatry. 1999;156:646-649.
114 Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry. 2002;159:477-479.
115 Garcia-Toro M, Mayol A, Arnillas H, et al. Modest adjunctive benefit with transcranial magnetic stimulation in medication-resistant depression. J Affect Disord. 2001;64:271-275.
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117 Hasey G. Transcranial magnetic stimulation in the treatment of mood disorder: a review and comparison with electroconvulsive therapy. Can J Psychiatry. 2001;46:720-727.
118 Kirkcaldie MT, Pridmore SA, Pascual-Leone A. Transcranial magnetic stimulation as therapy for depression and other disorders. Aust N Z J Psychiatry. 1997;31:264-272.
119 Manes F, Jorge R, Morcuende M, et al. A controlled study of repetitive transcranial magnetic stimulation as a treatment of depression in the elderly. Int Psychogeriatr. 2001;13:225-231.
120 Pridmore S. Substitution of rapid transcranial magnetic stimulation treatments for electroconvulsive therapy treatments in a course of electroconvulsive therapy. Depress Anxiety. 2000;12:118-123.
121 Szuba MP, O'Reardon JP, Rai AS, et al. Acute mood and thyroid stimulating hormone effects of transcranial magnetic stimulation in major depression. Biol Psychiatry. 2001;50:22-27.
122 Teneback CC, Nahas Z, Speer AM, et al. Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS. J Neuropsychiatry Clin Neurosci. 1999;11:426-435.
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- Reviewer: EBSCO CAM Review Board
- Review Date: 08/2013
- Update Date: 08/22/2013