Return to Index
Principal Proposed Natural Treatments
Other Proposed Natural Treatments
- Adrenal Extract
- Astha-15 (an Ayurvedic Herbal Combination )
- Brahmi ( Bacopa monniera )
- Betaine Hydrochloride
- Carum copticum (Ajwain)
- Coenzyme Q10 (CoQ10)
- Elimination Diet
- Essential Fatty Acids ( Omega-3 and Omega-6 Fatty Acids)
- Essential Oil of Eucalyptus
- Fish Oil
- Flaxseed Oil
- Food Allergen Elimination Diet
- GLA from Evening Primrose Oil
- Green-lipped Mussel
- Ivy Leaf
- Lobelia inflata
- Oligomeric Proanthocyanidins (OPCs)
- Osteopathic Manipulation
- Relaxation Therapy
- Sublingual Immunotherapy
- Vitamin B 6
- Vitamin B 12
- Vitamin E
- Yerba Santa
Principal Proposed Natural Treatments
Other Proposed Natural Treatments
Other Herbs and Supplements
Other Alternative Therapies
1 Shivpuri DN, Singhal SC, Parkash D. Treatment of asthma with an alcoholic extract of Tylophora indica : a crossover, double-blind study. Ann Allergy. 1972;30:407-412.
2 Shivpuri DN, Menon MPS, Prakash D. A crossover double-blind study on Tylophora indica in the treatment of asthma and allergic rhinitis. J Allergy. 1969;43:145-150.
3 Mathew KK, Shivpuri DN. Treatment of asthma with alkaloids of Tylophora indica : a double-blind study. Aspects Allergy Appl Immunol. 1974;7:166-179.
4 Gupta S, George P, Gupta V, et al. Tylophora indica in bronchial asthma—a double-blind study. Indian J Med Res. 1979;69:981-989.
5 Gopalakrishnan C, Shankaranarayanan D, Nazimudeen SK, et al. Effect of tylophorine, a major alkaloid of Tylophora indica , on immunopathological and inflammatory reactions. Indian J Med Res. 1980;71:940-948.
6 Udupa AL, Udupa SL, Guruswamy MN. The possible site of anti-asthmatic action of Tylophora asthmatica on pituitary-adrenal axis in albino rats. Planta Med. 1991;57:409-413.
7 Nandi M. Physical, chemical and biological assay of Tylophora indica mother tincture-a comparative study. Br Homeopath J. 1999;88:161-165.
8 Wagner H. Search for new plant constituents with potential antiphlogistic and antiallergic activity. Planta Med. 1989;55:235-241.
9 Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res. 1998;3:511-514.
10 Kreutner W, Chapman RW, Gulbenkian A, et al. Bronchodilatory and antiallergy activity of forskolin. Eur J Pharmacol. 1985;111:1-8.
11 Yousif MH, Thulesius O. Forskolin reverses tachyphylaxis to the bronchodilator effects of salbutamol: an in-vitro study on isolated guinea-pig trachea. J Pharm Pharmacol. 1999;51:181-186.
12 Bauer K, Dietersdorfer F, Sertl K, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther. 1993;53:76-83.
13 Hatch GE. Asthma, inhaled oxidants, and dietary antioxidants. Am J Clin Nutr. 1995;61(suppl 3):625S-630S.
14 Bielory L, Gandhi R. Asthma and vitamin C. Ann Allergy. 1994;73:89-99.
15 Wright J. Vitamin B12: powerful protection against asthma. Int Clin Nutr Rev. 1989;9:185-188.
16 Collipp PJ, Goldzier S III, Weiss N, et al. Pyridoxine treatment of childhood bronchial asthma. Ann Allergy. 1975;35:93-97.
17 Sur S, Camara M, Buchmeier A, et al. Double-blind trial of pyridoxine (vitamin B6) in the treatment of steroid-dependent asthma. Ann Allergy. 1993;70:147-152.
18 Ziolo G, Samochowiec L. Study on clinical properties and mechanisms of action of Petasites in bronchial asthma and chronic obstructive bronchitis. Pharm Acta Helv. 1998;72:378-380.
19 Scheidegger C, Dahinden C, Wiesmann U. Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. Pharm Acta Helv. 1998;72:376-378.
20 Onorato J, Merland N, Terral C, et al. Placebo-controlled double-blind food challenge in asthma. J Allergy Clin Immunol. 1986;78:1139-1146.
21 Dry J, Vincent D. Effect of a fish oil diet on asthma: results of a one-year double-blind study. Int Arch Allergy Immunol. 1991;95:156-157.
22 Stenius-Aarniala B, Aro A, Hakulinen A, et al. Evening primrose oil and fish oil are ineffective as supplementary treatment of bronchial asthma. Ann Allergy. 1989;62:534-547.
23 Picado C, Castillo JA, Schinca N, et al. Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. Thorax. 1988;43:93-97.
24 Arm J. The effects of dietary supplementation with fish oil on asthmatic responses to antigen. J Allergy Clin Immunol. 1988;81:183.
25 Stenius-Aarniala B, Aro A, Hakulinen A, et al. Symptomatic effects of evening primrose oil, fish oil, and olive oil in patients with bronchial asthma. Ann Allergy. 1985;55:330.
26 Thien FCK, Woods RK, Walters EH. Oily fish and asthma—a fishy story? Med J Aust. 1996;164:135-136.
27 Arm JP, Thien FCK, Lee TH. Leukotrienes, fish oil, and asthma. Allergy Proc. 1994;15:129-134.
28 Lee TH, Arm JP. Prospects for modifying the allergic response by fish oil diets. Clin Allergy. 1986;16:89-100.
29 Woods RK, Thien FC, Abramson MJ. Dietary marine fatty acids (fish oil) for asthma. Cochrane Database Syst Rev. 2000;1-12.
30 Nielsen NH, Bronfort G, Bendix T, et al. Chronic asthma and chiropractic spinal manipulation: a randomized clinical trial. Clin Exp Allergy. 1995;25:80-88.
31 Monteleone CA, Sherman AR. Nutrition and asthma. Arch Intern Med. 1997;157:23-34.
32 Rolla G, Bucca C, Arossa W, et al. Magnesium attenuates methacholine-induced bronchoconstriction in asthmatics. Magnesium. 1987;6:201-204.
33 Berger D, Nolte D. Acupuncture-has it a demonstrable bronchospasmolytic effect in bronchial asthma? [in German; English abstract]. Med Klin. 1975;70:1827-1830.
34 Davis PA, Chang C, Hackman RM, et al. Acupuncture in the treatment of asthma: a critical review. Allergol Immunopathol (Madr). 1998;26:263-271.
35 Kleijnen J, ter Riet G, Knipschild P. Acupuncture and asthma: a review of controlled trials. Thorax. 1991;46:799-802.
36 Biernacki W, Peake MD. Acupuncture in treatment of stable asthma. Respir Med. 1998;92:1143-1145.
37 Chow OKW, So SY, Lam WK, et al. Effect of acupuncture on exercise-incuded asthma. Lung. 1983;161:321-326.
38 Balon J, Aker PD, Crowther ER, et al. A comparison of active and simulated chiropractic manipulation as adjunctive treatment for childhood asthma. N Engl J Med. 1998;339:1013-1020.
39 Huntley A, White AR, Ernst E. Relaxation therapies for asthma: a systematic review Thorax. 2002;57:127-131.
40 Hosseini S, et al. Pycnogenol® in the management of asthma. J Med Food. 2001;4:201-210
41 Nagakura T, Matsuda S, Shichijyo K, et al. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. Eur Respir J. 2000;16:861-865.
42 Emelyanov A, Fedoseev G, Krasnoschekova O, et al. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur Respir J. 2002;20:596-600.
43 Urata Y, Yoshida S, Irie Y, et al. Treatment of asthma patients with herbal medicine TJ-96: a randomized controlled trial. Respir Med. 2002;96:469-474.
44 Neuman I, Nahum H, Ben-Amotz A. Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. Allergy. 2000;55:1184-1189.
45 Neuman I, Nahum H, Ben-Amotz A. Prevention of exercise-induced asthma by a natural isomer mixture of beta-carotene. Ann Allerg Asthma Immunol. 1999;82:549-553.
46 Mihrshahi S, Peat JK, Marks GB, et al. Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS). J Allergy Clin Immunol. 2003;111:162-168.
47 Juergens UR, Dethlefsen U, Steinkamp G, et al. Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial. Respir Med. 2003;97:250-256.
48 Hackman RM, Stern JS, Gershwin ME. Hypnosis and asthma: a critical review. J Asthma. 2000;37:1-15.
49 Field T, Henteleff T, Hernandez-Reif M, et al. Children with asthma have improved pulmonary functions after massage therapy. J Pediatr. 1998;132:854-858.
50 Lewith GT, Watkins AD. Unconventional therapies in asthma: an overview. Allergy. 1996;51:761-769.
51 Lau BH, Riesen SK, Truong KP, et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 2005;41:825-832.
52 Hofmann D, Hecker M, Volp A. Efficacy of dry extract of ivy leaves in children with bronchial asthma—a review of randomized controlled trials. Phytomedicine. 2003;10:213-220.
53 Fogarty A, Lewis S, Scrivener S, et al. Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial. Clin Exp Allergy. 2003;33:1355-1359.
54 Hughes R, Goldkorn A, Masoli M, et al. Use of isotonic nebulised magnesium sulphate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomised placebo-controlled trial. Lancet. 2003;361:2114-2117.
55 Mickleborough TD, Murray RL, Ionescu AA, et al. Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med. 2003 Aug 6. [Epub ahead of print].
56 Sutherland ER, Ellison MC, Kraft M, et al. Elevated serum melatonin is associated with the nocturnal worsening of asthma. J Allergy Clin Immunol. 2003;112:513-517.
57 Sutherland ER, Martin RJ, Ellison MC, et al. Immunomodulatory effects of melatonin in asthma. Am J Respir Crit Care Med. 2002;166:1055-1061.
58 Campos FL, Da Silva-Junior FP, De Bruin VM, et al. Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med. 2004 Aug 11. [Epub ahead of print]
59 Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, et al. Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone. Clin Exp Immunol. 2004;138:317-22.
60 Pearson PJ, Lewis SA, Britton J, et al. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax. 2004;59:652-656.
61 Schou AJ, Heuck C, Wolthers OD. Does vitamin D administered to children with asthma treated with inhaled glucocorticoids affect short-term growth or bone turnover? Pediatr Pulmonol. 2003;36:399-404.
62 Homik J, Suarez-Almazor ME, Shea B, et al. Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst Rev. 2000;2:CD000952.
63 Cooper S, Oborne J, Newton S, et al. Effect of two breathing exercises (Buteyko and pranayama) in asthma: a randomised controlled trial. Thorax. 2003;58:674-679.
64 Bowler DS, Green A, Mitchell CA. Buteyko breathing techniques in asthma: a blinded randomised controlled trial. MJA. 1998;169:575-578.
65 Cooper S, Oborne J, Newton S, et al. Effect of two breathing exercises (Buteyko and pranayama) in asthma: a randomised controlled trial. Thorax. 2003;58:674-679.
66 Gonzalez-Sanchez R, Trujillo X, Trujillo-Hernandez B, et al. Forskolin versus sodium cromoglycate for prevention of asthma attacks: a single-blinded clinical trial. J Int Med Res. 2006;34:200-207.
67 Hsu CH, Lu CM, Chang TT, et al. Efficacy and safety of modified Mai-Men-Dong-Tang for treatment of allergic asthma. Pediatr Allergy Immunol. 2005;16:76-81.
68 Falk B, Gorev R, Zigel L, et al. Effect of lycopene supplementation on lung function after exercise in young athletes who complain of exercise-induced bronchoconstriction symptoms. Ann Allergy Asthma Immunol. 2005;94:480-485.
69 Murali PM, Rajasekaran S, Krishnarajasekar OR, et al. Plant-Based Formulation for Bronchial Asthma: A Controlled Clinical Trial to Compare Its Efficacy with Oral Salbutamol and Theophylline. Respiration. 2005 Nov 22. [Epub ahead of print]
70 Gontijo-Amaral C, Ribeiro MA, Gontijo LS, et al. Oral magnesium supplementation in asthmatic children: a double-blind randomized placebo-controlled trial. Eur J Clin Nutr. 2006 Jun 21. [Epub ahead of print]
71 Blitz M, Blitz S, Hughes R, et al. Aerosolized magnesium sulfate for acute asthma: a systematic review. Chest. 2005;128:337-344.
72 Mickleborough TD, Lindley MR, Ionescu AA, Fly AD. Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest. 2006;129;39-49.
73 Petrigni G, Allegra L. Aerosolised hyaluronic acid prevents exercise-induced bronchoconstriction, suggesting novel hypotheses on the correction of matrix defects in asthma. Pulm Pharmacol Ther. 2006 Jan 3. [Epub ahead of print]
74 Sabina AB, Williams AL, Wall HK, et al. Yoga intervention for adults with mild-to-moderate asthma: a pilot study. Ann Allergy Asthma Immunol. 2005;94:543-548.
75 Guiney PA, Chou R, Vianna A, et al. Effects of osteopathic manipulative treatment on pediatric patients with asthma: a randomized controlled trial. J Am Osteopath Assoc. 2005;105:7-12.
76 Bernstein WK, Khastgir T, Khastgir A, et al. Lack of effectiveness of magnesium in chronic stable asthma. A prospective, randomized, double-blind, placebo-controlled, crossover trial in normal subjects and in patients with chronic stable asthma. Arch Intern Med. 1995;155:271-276 .
77 Gvozdjakova A, Kucharska J, Bartkovjakova M, et al. Coenzyme Q10 supplementation reduces corticosteroids dosage in patients with bronchial asthma. Biofactors. 2006;25:235-240.
78 Niu CK, Chen WY, Huang JL, et al. Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: a multi-center, double-blind, randomized, and placebo-controlled study in Taiwan. Respir Med. 2006;100:1374-1383.
79 Ram FS, Robinson SM, Black PN. Effects of physical training in asthma: a systematic review. Br J Sports Med. 2000;34:162-167.
80 Shaheen SO, Newson RB, Rayman MP, et al. Randomised, double-blind, placebo-controlled trial of selenium supplementation in adult asthma. Thorax. 2007 Jan 18. [Epub ahead of print]
81 Boskabady MH, Alizadeh M, Jahanbin B. Bronchodilatory effect of Carum copticum in airways of asthmatic patients. Therapie. 2007;62:23-29.
82 Tecklenburg SL, Mickleborough TD, Fly AD, et al. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir Med. 2007 Apr 4. [Epub ahead of print]
83 Rajaram D. A preliminary clinical trial of Picrorrhiza kurroa in bronchial asthma. Indian J Pharmacol. 1975;7:95-96.
84 Shah BK, Kamat SR, Sheth UK. Preliminary report of use of Picrorrhiza kurroa root in bronchial asthma. J Postgrad Med. 1977;23:118-120.
85 Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med. 1983;29:89-95.
86 Thomas M, Sheran J, Smith N, et al. AKL1, a botanical mixture for the treatment of asthma: a randomised, double-blind, placebo-controlled, cross-over study. BMC Pulm Med. 2007;7:4.
87 Giovannini M, Agostoni C, Riva E, et al. A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Pediatr Res. 2007 Jun 25. [Epub ahead of print]
88 Cowie RL, Conley DP, Underwood MF, Reader PG. A randomised controlled trial of the Buteyko technique as an adjunct to conventional management of asthma. Respir Med. 2008 Jan 30
89 Wood LG, Garg ML, Powell H, Gibson PG. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: Proof of concept. Free Radic Res. 2008;42:94-102.
90 Olsen SF, Osterdal ML, Salvig JD, et al. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr. 2008;88:167-175.
91 Schubert R, Kitz R, Beermann C, et al. Effect of n-3 polyunsaturated fatty acids in asthma after low-dose allergen challenge. Int Arch Allergy Immunol. 2008 Nov 11. [Epub ahead of print]
92 Biltagi MA, Baset AA, Bassiouny M, Kasrawi MA, Attia M. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatr. 2009;98:737-42.
93 Vempati R, Bijlani RL, Deepak KK. The efficacy of a comprehensive lifestyle modification programme based on yoga in the management of bronchial asthma: a randomized controlled trial. BMC Pulm Med. 2009;9:37.
94 van der Aa LB, van Aalderen WM, Heymans HS, et al. Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis. Allergy. 2010 Jun 17. [Epub ahead of print]
95 Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med. 2011;364(8):701-709.
- Reviewer: EBSCO CAM Review Board
- Review Date: 07/2012
- Update Date: 07/25/2012