Return to Index
Medications for Peripheral Artery Disease (PAD)
- Medications that improve flow through narrowed arteries
- Medications that thin the blood so that it does not clot as easily
- Recombinant tissue plasminogen activator (rt-PA, alteplase)
- Runny nose, sore throat
- Bowel changes
- Increased bleeding risk
- Bleeding, especially in the area of stomach ulcers or recent surgical sites
- Rare allergic reactions
- Serious heart and lung events
- Allergic reactions
- Too few platelets—thrombocytopenia
- Peptic ulcers
- Increased bleeding tendency
- New or worsening symptoms
- Medication side effects
- Foot wounds that do not heal
- Foot infections
- Take them as directed—not more, not less, not at a different time.
- Do not stop taking them without consulting your doctor.
- Don’t share them with anyone else.
- Know what effects and side effects to expect, and report them to your doctor.
- If you are taking more than one drug, even if it is over-the-counter, be sure to check with a physician or pharmacist about drug interactions.
- Plan ahead for refills so you don’t run out.
American Family Physician. Peripheral vascular disease: diagnosis and treatment. Am Fam Physician. 2006;73(11):1971-1976.
Hills AJ, Shalhoub J, et al. Peripheral arterial disease. Br J Hosp Med (Lond). 2009;70(10):560-565.
How is peripheral arterial disease treated? National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/pad/treatment.html. Updated June 2, 2014. Accessed June 23, 2014.
Peripheral arterial disease (PAD) of lower extremities. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated June 13, 2014. Accessed June 23, 2014.
Prevention and treatment of PAD. American Heart Association website. Available at: http://www.heart.org/HEARTORG/Conditions/More/PeripheralArteryDisease/Prevention-and-Treatment-of-PAD%5FUCM%5F301308%5FArticle.jsp. Updated February 26, 2014. Accessed June 23, 2014.
11/18/2011 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed.: Rooke TW, Hirsch AT, Misra S, et al. 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124(18):2020-2045.
- Reviewer: Michael J. Fucci, DO; Brian Randall, MD
- Review Date: 08/2013
- Update Date: 00/62/2014