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Medication for Women with Advanced Breast Cancer
Trastuzumab May Delay Cancer Progression
- Damage to the lungs
- Life-threatening allergic reaction
- Breast cancer after surgical treatment along with or after chemotherapy
- Breast cancer that has spread to other parts of the body along with or after chemotherapy
- Stomach cancer or cancer at the junction of the stomach and esophagus that have spread to other parts of the body along with chemotherapy
American Cancer Society http://www.cancer.org
National Cancer Institute http://www.cancer.gov
Canadian Cancer Society http://cancer.ca
Canadian Breast Cancer Foundation http://www.cbcf.org
Gianni L, Dafni U, Gelber RD, et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial. Lancet Oncol . 2011;12(3):236-244,
HER2 inhibitors for breast cancer. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what. Updated December 17, 2012. Accessed December 21, 2012.
Herceptin. Daily Med website. Available at: http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=492dbdb2-077e-4064-bff3-372d6af0a7a2. Updated October 2010. Accessed December 21, 2012.
Hortobagyi GN. Trastuzumab in the treatment of breast cancer. N Engl J Med. 2005;353:1734-1736.
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after Adjuvant Chemotherapy in HER2-positive Breast Cancer. N Engl J Med. 2005;353(16):1659-1672.
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353:1673-1684.
Slamon DJ, Leyland-Jones B, Shak S, et al. Concurrent administration of anti-HER2 monoclonal antibody and first-line chemotherapy for HER2-overexpressing metastatic breast cancer: A phase III, multinational, randomized, controlled trial. N Engl J Med. 2001;344:783-792.
Smith I, Procter M, Gelber RD, et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet. 2007;369(9555):29-36.
Trastuzumab. American Cancer Society website. Available at: http://www.cancer.org/treatment/treatmentsandsideeffects/guidetocancerdrugs/trastuzumab. Updated November 3, 2010. Accessed December 21, 2012.
Trastuzumab. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated September 10, 2012. Accessed December 21, 2012.
- Reviewer: Brian Randall, MD
- Review Date: 12/2012
- Update Date: 12/21/2012