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(Hemophilia A—Factor VIII Deficiency; Classic Hemophilia; Hemophilia B—Factor IX Deficiency; Christmas Disease)
- Hemophilia A (classic hemophilia)—accounts for 80% of all hemophilia (1 in 5,000 males), caused by too little factor VIII
- Hemophilia B (Christmas disease)—occurs in 1 in 20,000 males, caused by too little factor IX
|Genetic Outcome Possibilities|
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- Easy bruising
- Severe nosebleeds
- Blood in urine
- Blood in stools
- Heavy bleeding after minor cuts, bumps, dental work, or other trauma
- Joint pain
- Heavy menstrual bleeding in women who are carriers
- Tests to see how well your blood clots and blood tests to look for other causes of bleeding problems
- Blood tests to measure the amounts of clotting factors present
Blood Factor Concentrate
- Good dental care is important. It may decrease the risk of major dental work.
Be aware of the effect of high impact activities:
- Take extra care to protect the head from injuries.
- People with severe hemophilia should avoid activities that include a high risk of collision.
Avoid drugs that can also aggravate bleeding problems such as:
- Blood thinners, such as aspirin or heparin
- Antiplatelets, such as warfarin
- Certain analgesics, such as nonsteroidal anti-inflammatory drugs
American Society of Hematology http://www.hematology.org
National Hemophilia Foundation http://www.hemophilia.org
Caring for Kids http://www.caringforkids.cps.ca
Network of Rare Blood Disorder Organizations http://www.hemophilia.ca
Explore hemophilia. National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia. Updated July 1, 2011. Accessed June 25, 2013.
Hemophilia A. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated May 10, 2013. Accessed June 25, 2013.
Hemophilia B. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated May 10, 2013. Accessed June 25, 2013.
10/24/2012 DynaMed's Systematic Literature Surveillance. http://www.ebscohost.com/dynamed/what.php: Broderick CR, Herbert RD, et al. Association between physical activity and risk of bleeding in children with hemophilia. JAMA. 2012 Oct 10;308(14):1452-9.
4/24/2014 DynaMed's Systematic Literature Surveillance. http://www.ebscohost.com/dynamed: US Food and Drug Administration. FDA approves first long-acting recombinant coagulation Factor IX concentrate for patients with Hemophilia B. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm391037.htm. Published March 28, 2014. Accessed April 24, 2014.
- Reviewer: Igor Puzanov, MD; Brian Randall, MD
- Review Date: 06/2013
- Update Date: 04/28/2014